Effect of Leaf and Fruit Extract of Fig Tree (Ficus Carica) on Glucose Level of Blood
Keywords:
Fig leaf, fig fruit, glucose level of blood
Abstract
Ficus carica (fig tree) leaf and fruit has long been observed to significantly affect blood glucose level. Fruit and leaves are known to contain polyphenol compound that plays a role in the glucose level of blood. However, the comparative study of these two extracts is not so much been explored. We investigate the effect of the fruit and leaf of a fig tree on the glucose level of blood. The method used in this experiment is using a completely randomized design (CRD) which consisted of 3 treatments, namely control (aquadest), fig leaf extract, and fig fruit extract. The extract is given orally for 14 days straight to a mouse (Mus musculus) with a dosage equal to 300 mg/kgW/day. These studies show that the blood glucose level of a mouse is lowered to 1,31% for a fig leaf and 1,96% for a fig fruit from a normal level. It can be concluded that a fig tree's leaf and fruit extract can increase the blood glucose level.
References
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Fedoroff, N. V. 2002. Cross-talk in abscisic acid signaling. Science's STKE, 2002(140), re10-re10.
Finkelstein, R., Reeves, W., Ariizumi, T., & Steber, C. 2008. Molecular aspects of seed dormancy.
Horozić, E., Merzić, S., & Šehanović, A. 2021. Influence of solvents on polyphenol content and antioxidant activity of fig leaf extracts obtained by maceration and ultrasonic extraction International Journal of Advanced Chemistry Influence of solvents on polyphenol content and antioxidant activity of fig leaf extracts obtained by maceration and ultrasonic extraction. Artic Int J Adv Chem, 9, 70-73.
Imran, A., K., J.R., Varnika, S., 2011. A review on traditional, pharmacological, pharmacognostic properties of Ficus carica. International Research Journal of Pharmacy 2, 124–127.
Joyce L K. 2006. Buku Saku Pemeriksaan Laboratorium dan Diagnostik dengan implikasi keperawatan. Jakarta: EGC.
Milton, K., & Demment, M. W. 1988. Digestion and passage kinetics of chimpanzees fed high and low fiber diets and comparison with human data. The Journal of nutrition, 118(9), 1082-1088.
Nirwana I, Rianti D, Helal Soekartono R, Listyorini RD, Basuki DP. Antibacterial activity of fig leaf (Ficus carica Linn.) extract against Enterococcus faecalis and its cytotoxicity effects on fibroblast cells. Vet World. 2018;11(3):342–7.
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Nugrahani, S. S.2012. Ekstrak Akar, Batang dan Daun Herba Meniran dalam Menurunkan Kadar Glukosa Darah. Jurnal Kesehatan Masyarakat, 8(1), 51 – 59.
Ohnishi, M., Matuo, T., Tsuno, T., Hosoda, A., Nomura, E., Taniguchi, H., ... & Morishita, H. 2004. Antioxidant activity and hypoglycemic effect of ferulic acid in STZ-induced diabetic mice and KK-A^{y} mice. Biofactors, 21(1-4), 315-319.
Song, J., Kwon, O., Chen, S., Daruwala, R., Eck, P., Park, J. B., & Levine, M. 2002. Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and glucose. Journal of Biological Chemistry, 277(18), 15252-15260.
Stephen Irudayaraj, S., Christudas, S., Antony, S., Duraipandiyan, V., Naif Abdullah, A. D., & Ignacimuthu, S. 2017. Protective effects of Ficus carica leaves on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells in type 2 diabetic rats. Pharmaceutical biology, 55(1), 1074-1081.
Subiyono., Martsiningsih, M. A., & Gabrella, D. 2016. Gambaran Kadar Glukosa Darah Metode GOD-PAP (Glucose Oxsidase – Peroxidase Aminoantypirin) Sampel Serum dan Plasma EDTA (Ethylen Diamin Terta Acetat). Jurnal Teknologi Laboratorium, 5(1), 45 – 48.
Takahashi, T., Okiura, A., & Kohno, M. 2017. Phenylpropanoid composition in fig (Ficus carica L.) leaves. Journal of natural medicines, 71(4), 770-775.
Trad, M., Le Bourvellec, C., Gaaliche, B., Renard, C. M., & Mars, M. 2014. Nutritional compounds in figs from the southern Mediterranean region. International Journal of Food Properties, 17(3), 491-499.
Veberic, R., & Mikulic-Petkovsek, M. 2016. Phytochemical composition of common fig (Ficus carica L.) cultivars. In Nutritional composition of fruit cultivars (pp. 235-255). Academic Press.
Vinson, J. A. 1999. The Functional Food Properties of Figs. American Association of Cereal Chemist, 44(2), 82 – 87.
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Zhang, Y., Kilambi, H. V., Liu, J., Bar, H., Lazary, S., Egbaria, A., ... & Shani, E. 2021. ABA homeostasis and long-distance translocation are redundantly regulated by ABCG ABA importers. Science advances, 7(43), eabf6069.
Zocchi, E., Hontecillas, R., Leber, A., Einerhand, A., Carbo, A., Bruzzone, S., ... & Bassaganya-Riera, J. 2017. Abscisic acid: a novel nutraceutical for glycemic control. Frontiers in nutrition, 4, 24.
